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2-Nitrophenol

2-Nitrophenol, also known as o-nitrophenol Ortho Nitro Phenol or ONP, belongs to the phenol family, characterized by a hydroxyl group (-OH) attached to a benzene ring. Its chemical formula is C6H5NO3, and it consists of a nitro group (-NO2) in the ortho position relative to the hydroxyl group. This unique arrangement gives rise to its distinct properties. 2-Nitrophenol exists as a Light yellow coloured free flowing crystals; with a slightly acidic character due to the presence of the hydroxyl group. It has a melting point of around 45°C and a boiling point of approximately 213°C.

  • Chemical Formula : C6H5NO3
  • CAS No : 614-75-5
  • EC No : 210-393-2
  • Assay by HPLC : Minimum 98.00%
  • Chlorides as NaCl : Maximum 0.50%
  • Moisture : Maximum 0.50%
  • Packaging : The product is packaged as 25 kg net weight in HDPE woven bags with polyliner.

Application

2-Nitrophenol derivatives find use in the pharmaceutical industry, particularly in the synthesis of various drugs. They exhibit antimicrobial, anti-inflammatory, and analgesic properties. Furthermore, 2-nitrophenol derivatives have shown potential in cancer research, acting as cytotoxic agents against certain tumour cells.

2-Nitrophenol serves as an intermediate compound in the production of dyes and pigments. Its reactivity allows for the introduction of additional functional groups, resulting in a wide range of vibrant and long-lasting colorants used in textiles, plastics, and other materials.

It is used as an intermediate in the manufacture of several azo dyes, including CI Solvent Red 8, which is used for colouring synthetic resins, lacquers, inks and wood stains. It is used as an intermediate to create dye in semi-permanent hair colouring products to produce red and gold-blond shades.

The derivatives of 2-nitrophenol can have applications in the field of agrochemistry. The compound itself is a nitro-substituted phenol and is not generally used for agricultural purposes. However, some derivatives of 2-nitrophenol or compounds with similar structures might find use in the agrochemical industry.

For instance, the chemical structure of 2-nitrophenol could potentially serve as a starting point for the synthesis of certain pesticides, herbicides, or fungicides. By chemically modifying the compound and introducing various functional groups, researchers can design molecules with specific pesticidal or agricultural properties.

2-Nitrophenol has gained attention in environmental studies due to its occurrence as a pollutant. It is generated as a by-product during the manufacture of pesticides and pharmaceuticals. Understanding its behaviour and impact on the environment aids in developing effective remediation strategies.

2-Nitrophenol serves as an essential building block for the synthesis of various chemical intermediates. These intermediates find applications in the production of herbicides, fungicides, and other agrochemicals. Additionally, they are utilized in the synthesis of rubber accelerators, antioxidants, and corrosion inhibitors.

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Differences between 2-Nitrophenol and 4-Nitrophenol

2-Nitrophenol and 4-Nitrophenol are two isomeric compounds that belong to the phenol family. While they share some similarities in terms of their chemical structure and properties, they also exhibit distinct differences. Let's explore some of the key differences between these two compounds:

The primary difference between 2-nitrophenol and 4-nitrophenol lies in the position of the nitro group (-NO2) on the benzene ring. In 2-nitrophenol, the nitro group is attached to the ortho position relative to the hydroxyl group (-OH), whereas in 4-nitrophenol, it is attached to the para position.

Due to the different arrangements of the nitro group, 2-nitrophenol and 4-nitrophenol exhibit variations in their melting and boiling points. Generally, 2-nitrophenol has a lower melting point and boiling point compared to 4-nitrophenol. The melting point of 2-nitrophenol is around 45°C, while that of 4-nitrophenol is higher, around 113°C. The boiling point of 2-nitrophenol is approximately 213°C, whereas 4-nitrophenol has a higher boiling point, around 279°C.

The position of the nitro group also affects the acidity of these compounds. 2-Nitrophenol is slightly more acidic than 4-nitrophenol due to the proximity of the hydroxyl and nitro groups, which enhances the resonance stabilization of the phenoxide ion formed after deprotonation.

Another noticeable difference between these compounds is their colour. 2-Nitrophenol appears as a light yellow free flowing crystals, while 4-nitrophenol is typically a pale/gold yellow or light brown solid.

The reactivity and applications of 2-nitrophenol and 4-nitrophenol can differ due to the different positions of the nitro group. The ortho position of the nitro group in 2-nitrophenol makes it more reactive and suitable for various chemical transformations. It finds applications in pharmaceuticals, dyes, and as a building block for chemical intermediates. On the other hand, 4-nitrophenol is commonly used as a starting material for the production of paracetamol (acetaminophen), a widely used analgesic.

Packaging

The product is packed in Fibre Drums with Net Weight of 25 kg and having a Liner inside for added protection. Or The product is packed in HDPE woven bags with Net Weight of 50 kg and LDPE Liner inside for added protection.

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Conclusion

2-Nitrophenol, with its distinctive chemical structure and properties, has proved to be a versatile compound with a myriad of applications. Its presence in pharmaceuticals, dyes, and agrochemicals highlights its significance in different industries. However, its environmental implications cannot be overlooked, emphasizing the need for sustainable practices and effective waste management. Further research and development in the field of 2-nitrophenol can lead to the discovery of novel applications and methods to mitigate its environmental impact. As we continue to explore the potential of this compound, we unlock new opportunities for innovation and advancement in various scientific fields.